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KMID : 0191120010160010031
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Journal of Korean Medical Science
2001 Volume.16 No. 1 p.31 ~ p.38
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Influence of Stent Expansion States on Platelet Deposition in an Extracorporeal Porcine Arteriovenous Shunt Model Using a Multichannel Perfusion Chamber
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Taehoon Ahn
Eakkyun Shin/Yahye Merhi/Pierre Thai/Luc Bilodeau
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Abstract
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Limited data are available about incomplete stent expansion (SE) on platelet deposition (PD). We examined PD following different SE using an extracorporeal porcine arteriovenous shunt model to which a perfusion chamber with four parallel silastic tubes were connected. Blood flow was set at a 20 and 100 mL/min in 1.8 and 3.1 mm diameter tubes, respectively. P154 stents were deployed completely (Group A, n=15) or incompletely (Group B, n=15) in 1.8 mm (n=13) and 3.1 mm (n=17) tubes. 51Cr-labelled platelet autologous blood was injected 1 hr before the perfusion. After 15 min-perfusion, the testing tubes were assessed for radioactivity counts. In-stent cross sectional area was measured by intravascular ultrasound. There was a significant difference in PD between group A and B regardless of channel size (118±18.4 vs 261.4±52.1 pits × 106/cm2,p<0.05). With adjusted shear rate and similar stenosis, PD was similar in both tubes. In smaller 1.8 mm tubes, a stenosis as subtle as 10% was associated with a significant PD difference (226.1±20 vs 112.9±20.5 plts × 106/cm2,p<0.005). This model enabled a repetitive, simultaneous comparison of PD following different SE states. It seems that the quality of SE remains crucial in smaller channels.
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